We have had reports of transient issues with users trying to connect to CHPC file systems from their windows and mac desktops. We are working to troubleshoot the issue and will send another note when we either have resolved the issue or know more about the extent and the time to resolve.
- No network access to any CHPC resource
- Network down in INSCC Building
- Protected Environment VM farm will be down during this time window
- No access to virtual machines or services running on virtual machines
- No access to CHPC file systems - (i.e. mounts to your desktop)
- No access to HPC Clusters - The clusters will stay up and scheduling jobs
Files in /scratch will now be scrubbed based on atime (last accessed) rather than mtime (last modified)
- Poster Competition:
A New Role for Proteins
DNA encodes RNAs and RNAs encode proteins. This flow of cellular information is commonly referred to as the Central Dogma of Molecular Biology. However, a team of researchers discovered a notable exception to this rule where a protein can direct the synthesis of another protein, without an RNA template. This unusual mode of protein synthesis only occurs after normal protein synthesis has failed and appears to send a distress signal to the cell that something has gone awry.
The researchers first detected template-free protein synthesis by visualizing it directly by using a technique known as electron cryo-microscopy (cryo-EM). The image analysis, performed on the University of Utah Center for High Performance Computing cluster, required processing hundreds of thousands of 2D images to compute a 3D reconstruction of the cellular assembly. Once the researchers analyzed the structure and performed follow-up biochemical experiments, they knew they had stumbled upon an unexpected discovery. "In this case, we have a protein playing a role similar to that filled by messenger RNA," says Adam Frost, M.D., Ph.D., assistant professor at University of California, San Francisco (UCSF) and adjunct professor of biochemistry at the University of Utah, who led the research team. "I love this story because it blurs the lines of what we thought proteins could do." This work was featured in the January 2, 2015 issue of Science.